How to: maximize peak purity?

Have you ever collected what you believed to be a pure peak, only to run an NMR analysis and discover it’s not? Ensuring peak purity is a common hurdle in chromatography. Fortunately, modern instruments now include features designed to save you time and frustration.  

Detecting impurities

The Peak Purity function in Flash, Prep, and Prep SFC instruments provides a valuable solution. This feature scans your collected peak for spectral purity by analysing the UV profiles of underlying components. If there are any impurities with different UV characteristics, the system will flag them, displaying a green peak above your collected sample. 

Interpreting the results

A clean peak will show a straight green line above it, indicating that your sample is likely pure. However, it is essential to note that if impurities share the same UV profile as your target compound, they won’t be detected by this function. 

The benefits of using peak purity

Using the Peak Purity function can save you significant time and resources by helping you avoid NMR runs on impure samples. By identifying spectral differences early in the process, you can ensure more reliable analyses and meaningful results. 

Commencez dès aujourd'hui

Ready to streamline your analysis process? Check out the video tutorial to learn how to run the Peak Purity function. With just a few simple steps, you can ensure your collected samples are as pure as you expect.