{"id":2360,"date":"2023-01-03T15:07:51","date_gmt":"2023-01-03T14:07:51","guid":{"rendered":"https:\/\/chemspx.com\/instruments\/combiflash-nextgen-100\/"},"modified":"2026-04-27T15:40:35","modified_gmt":"2026-04-27T13:40:35","slug":"combiflash-nextgen-100-flash-chromatography-system-for-normal-and-reverse-phase-purifications","status":"publish","type":"instruments","link":"https:\/\/chemspx.com\/fr\/instruments\/combiflash-nextgen-100\/","title":{"rendered":"CombiFlash NextGen 100"},"content":{"rendered":"

Flash Chromatography System for normal and reverse phase purifications<\/h2>\n

What is the CombiFlash\u00ae NextGen 100?<\/strong><\/h3>\n

The CombiFlash\u00ae NextGen 100 from Teledyne Labs <\/span><\/span>is a flash chromatography system for both normal phase and reverse phase purifications<\/strong>. It operates at flow rates up to 100 mL\/min<\/strong> and pressures up to 150 psi (10 bar)<\/strong>, offering an economical solution for routine purification workflows.<\/p>\n

System design and performance<\/strong><\/h3>\n

The system can handle a wide range of purification needs while maintaining a compact and cost-effective setup. It supports collection of purified compounds in different rack sizes, allowing appropriate fraction volumes depending on column size.<\/p>\n

Flow and pressure capabilities include:<\/strong><\/p>\n

    \n
  • Flow rates from 1 to 100 mL\/min<\/li>\n
  • Operating pressure up to 150 psi (10 bar)<\/li>\n<\/ul>\n

    Focus Gradient Generator<\/strong><\/h3>\n

    The Focus Gradient Generator is integrated into PeakTrak\u00ae software and supports predictive method development. After a preset gradient run, the user can select a target peak, and the system automatically generates an optimized gradient method focused on that compound.<\/p>\n

    Key features<\/strong><\/h3>\n
      \n
    • Wider dynamic range UV detector with improved baseline correction for absorbing solvents<\/li>\n
    • Faster processing through a streamlined user interface<\/li>\n
    • Photo diode array (PDA) detection using UV and UV-Vis technology<\/li>\n
    • Real-time or post-run spectral display<\/li>\n
    • Fraction collection based on purity indicators<\/li>\n<\/ul>\n

      Detection and purification options<\/h3>\n

      The system supports multiple advanced detection and collection strategies:<\/p>\n

      Internal vapor sensor<\/strong>
      When the system detects vapors, it automatically stops operation.<\/p>\n

      Mass-directed purification<\/strong>
      Fraction collection can be based on matching the mass of the target compound, reducing the need for additional post-purification analysis and saving time.<\/p>\n

      ELSD detection<\/strong>
      An integrated evaporative light scattering detector (ELSD) allows collection of non-chromophoric and non-volatile compounds. It is fully integrated into the system, requiring no additional footprint. All parameters are automatically configured based on the solvent used or can be optimized for the separation.<\/p>\n

      Specifications\u00a0<\/strong><\/h3>\n
      \n\n\n\n\n\n\n\n\n
      Flow rate range<\/strong><\/th>\n1\u2013100\u202fmL\/min<\/td>\n<\/tr>\n
      Pressure limit<\/strong><\/th>\n150\u202fpsi (10\u202fbar)<\/td>\n<\/tr>\n
      Column sizes<\/strong><\/th>\n4\u2013330\u202fg<\/td>\n<\/tr>\n
      Sample size<\/strong><\/th>\n10\u202fmg\u201310\u202fg<\/td>\n<\/tr>\n
      User interface<\/strong><\/th>\n12\u202fin touchscreen (30.5\u202fcm)<\/td>\n<\/tr>\n
      Dimensions (H \u00d7 W \u00d7 D)<\/strong><\/th>\n26 \u00d7 14.1 \u00d7 17\u202fin (66 \u00d7 36 \u00d7 43\u202fcm)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

       <\/p>\n

      \"\"No more TLC plates for flash. Really?<\/strong><\/h3>\n

      Yes, really, with the Focused Gradient Generator for flash. Read the info here.<\/a><\/p>\n

       <\/p>\n