{"id":6391,"date":"2026-05-04T14:26:43","date_gmt":"2026-05-04T12:26:43","guid":{"rendered":"https:\/\/chemspx.com\/?post_type=instruments&#038;p=6391"},"modified":"2026-05-04T14:29:07","modified_gmt":"2026-05-04T12:29:07","slug":"razor-elevated-temperature-cleavage-system","status":"publish","type":"instruments","link":"https:\/\/chemspx.com\/nl\/instruments\/razor-elevated-temperature-cleavage-system\/","title":{"rendered":"Razor"},"content":{"rendered":"<h2 class=\"ml-0 mb-1 pl-0\">Elevated Temperature Cleavage System<\/h2>\n<p data-start=\"48\" data-end=\"328\">The Razor system elevates temperature peptide cleavage, enabling faster workflows and improved peptide purity. By using precision heated reactions, the system supports more complete removal of protecting groups while maintaining reliable and reproducible results.<\/p>\n<p data-start=\"667\" data-end=\"838\">Up to 12 peptides can be cleaved simultaneously in 30 minutes or less, providing a high-throughput approach where cleavage speed matches downstream purification workflows.<\/p>\n<h3 data-section-id=\"1g5sss\" data-start=\"506\" data-end=\"550\"><strong>Faster cleavage and accelerated workflows<\/strong><\/h3>\n<p data-start=\"552\" data-end=\"620\">The Razor system enables both rapid microcleavage and full cleavage:<\/p>\n<ul data-start=\"622\" data-end=\"898\">\n<li data-section-id=\"a55qf5\" data-start=\"622\" data-end=\"779\">Microcleavage can be performed in as little as 2 minutes, providing mass spectrometry-level confidence that amino acids are fully coupled before scale-up<\/li>\n<li data-section-id=\"1yio1qw\" data-start=\"780\" data-end=\"898\">Full cleavage after synthesis can be completed in 30 minutes or less, helping to accelerate purification workflows<\/li>\n<\/ul>\n<p>This allows laboratories to move from synthesis to purified peptides faster than with conventional methods.<\/p>\n<h3 data-section-id=\"tvuyug\" data-start=\"1009\" data-end=\"1064\"><strong>Improved peptide purity through elevated temperature<\/strong><\/h3>\n<p data-start=\"1370\" data-end=\"1621\">Elevated temperature accelerates removal of protecting groups, including more difficult ones such as Pbf. Heat increases molecular motion, improving access of cleavage and scavenging reagents to hydrophobic and sterically hindered regions of peptides.<\/p>\n<p data-start=\"1623\" data-end=\"1785\">This supports more complete cleavage and contributes to improved peptide purity, particularly in combination with automated microwave peptide synthesis workflows.<\/p>\n<h3 data-start=\"1623\" data-end=\"1785\"><strong>Reliability\u00a0<\/strong><\/h3>\n<p data-start=\"1829\" data-end=\"2037\">The Razor system is designed for high-throughput cleavage while minimizing impact on peptide synthesis instrumentation. Harsh cleavage reagents and scavengers can cause wear on automated peptide synthesizers.<\/p>\n<p data-start=\"2039\" data-end=\"2213\">The system uses a simple design without a complex valve block system, reducing the need for maintenance. Disposable vessels simplify cleanup and help maintain peptide purity.<\/p>\n<h3 data-section-id=\"bb1q2s\" data-start=\"2215\" data-end=\"2234\"><strong>Key capabilities<\/strong><\/h3>\n<ul data-start=\"2236\" data-end=\"2517\">\n<li data-section-id=\"1cgow8f\" data-start=\"2236\" data-end=\"2301\">Cleave up to 12 peptides in parallel at elevated temperatures<\/li>\n<li data-section-id=\"1y3bvr1\" data-start=\"2302\" data-end=\"2367\">More complete cleavage contributes to improved peptide purity<\/li>\n<li data-section-id=\"c2zobm\" data-start=\"2368\" data-end=\"2445\">Helps protect automated peptide synthesizers from harsh cleavage reagents<\/li>\n<li data-section-id=\"nhp7zj\" data-start=\"2446\" data-end=\"2517\">High-throughput cleavage designed for faster purification workflows<\/li>\n<\/ul>\n<p><script type=\"application\/ld+json\"> \n{ \n  \"@context\": \"https:\/\/schema.org\/\", \n  \"@type\": \"Product\", \n  \"name\": \"Liberty Lite 2.0\", \n  \"image\": \"https:\/\/chemspx.com\/wp-content\/uploads\/2026\/05\/razor.webp\", \n  \"description\": \"Elevated Temperature Cleavage System that enables faster workflows and improved peptide purity. Up to 12 peptides can be cleaved simultaneously in 30 minutes or less, providing a high-throughput approach where cleavage speed matches downstream purification workflows.\", \n  \"brand\": { \n    \"@type\": \"Brand\", \n    \"name\": \"CEM\" \n  }, \n  \"offers\": { \n    \"@type\": \"Offer\", \n    \"url\": \"https:\/\/chemspx.com\/instruments\/razor-elevated-temperature-cleavage-system\/\", \n    \"priceCurrency\": \"EUR\", \n    \"price\": \"0.00\", \n    \"availability\": \"https:\/\/schema.org\/InStock\", \n    \"seller\": { \n      \"@type\": \"Organization\", \n      \"name\": \"ChemSPX\", \n      \"url\": \"https:\/\/chemspx.com\", \n      \"logo\": \"https:\/\/chemspx.com\/wp-content\/uploads\/2023\/01\/Logo_ChemSPX-1.png\", \n      \"areaServed\": [ \n        { \"@type\": \"Country\", \"name\": \"Belgium\" }, \n        { \"@type\": \"Country\", \"name\": \"Netherlands\" }, \n        { \"@type\": \"Country\", \"name\": \"Luxembourg\" } \n      ] \n    } \n  } \n} \n<\/script><\/p>\n<p><script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [{\n    \"@type\": \"Question\",\n    \"name\": \"Why is elevated temperature used for peptide cleavage?\",\n    \"acceptedAnswer\": {\n      \"@type\": \"Answer\",\n      \"text\": \"Elevated temperature increases molecular motion, which improves the interaction between cleavage reagents, scavengers, and the peptide resin. This enhanced access supports faster and more complete removal of protecting groups, including sterically hindered and hydrophobic regions within complex peptides.\"\n    }\n  },{\n    \"@type\": \"Question\",\n    \"name\": \"How does the Razor system improve peptide purity?\",\n    \"acceptedAnswer\": {\n      \"@type\": \"Answer\",\n      \"text\": \"By accelerating the removal of protecting groups such as Pbf, elevated temperature cleavage ensures more complete deprotection. This reduces residual protecting group contamination, resulting in higher peptide purity, especially when used alongside automated or microwave\u2011assisted peptide synthesis.\"\n    }\n  },{\n    \"@type\": \"Question\",\n    \"name\": \"How many peptides can be cleaved simultaneously?\",\n    \"acceptedAnswer\": {\n      \"@type\": \"Answer\",\n      \"text\": \"The Razor system can cleave up to 12 peptides in parallel, making it suitable for high\u2011throughput peptide research environments where multiple sequences are processed simultaneously.\"\n    }\n  },{\n    \"@type\": \"Question\",\n    \"name\": \"What is microcleavage and why is it useful?\",\n    \"acceptedAnswer\": {\n      \"@type\": \"Answer\",\n      \"text\": \"Microcleavage is a rapid, small\u2011scale cleavage used to confirm synthesis success before scale\u2011up. With the Razor system, microcleavage can be completed in approximately 2 minutes, providing mass\u2011spectrometry\u2011level confidence that amino acids are fully coupled prior to committing additional resources.\"\n    }\n  },{\n    \"@type\": \"Question\",\n    \"name\": \"Can the Razor system protect peptide synthesizers from damage?\",\n    \"acceptedAnswer\": {\n      \"@type\": \"Answer\",\n      \"text\": \"Yes. Harsh cleavage reagents and scavengers can cause wear on automated peptide synthesizers. The Razor system separates cleavage from synthesis instrumentation, helping protect valuable synthesizers from chemical exposure and extending their operational lifetime.\"\n    }\n  },{\n    \"@type\": \"Question\",\n    \"name\": \"Why choose the Razor elevated temperature cleavage system?\",\n    \"acceptedAnswer\": {\n      \"@type\": \"Answer\",\n      \"text\": \"The Razor system combines speed, parallel processing, improved peptide purity, and instrument protection in a simple, reliable platform. It enables laboratories to complete peptide cleavage faster, with higher confidence and cleaner results, while keeping synthesis instruments isolated from harsh cleavage chemistry.\"\n    }\n  }]\n}\n<\/script><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Elevated Temperature Cleavage System designed for elevated temperature peptide cleavage, enabling faster workflows and improved peptide purity<\/p>","protected":false},"featured_media":6392,"template":"","country":[650,649],"brands":[658],"applications":[675,672],"markets":[],"class_list":["post-6391","instruments","type-instruments","status-publish","has-post-thumbnail","hentry","country-be","country-nl","brands-cem","applications-automated-cleavage","applications-peptide-synthesis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Razor | Elevated Temperature Cleavage System | ChemSPX<\/title>\n<meta name=\"description\" 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