CombiFlash NextGen 300

Flash Chromatography System for operation up to 300 psi (20 bar)

CombiFlash NextGen 300 is a flash chromatography system designed for purification workflows up to 300 psi (20 bar). It supports flow rates from 1 to 300 mL/min and is used for preparative separation of compounds in laboratory environments.

System performance

• Flow rates from 1 to 300 mL/min
• Operating pressure up to 150 psi (10 bar), upgradeable to 300 psi (20 bar)

The system is supports liquid injections at standard pressure, with the option to add a solid load injection valve to increase the pressure limit and expand application flexibility.

Detection and data handling

The system includes a wider dynamic range UV detector with improved baseline correction, enabling the use of absorbing solvents while maintaining signal stability. A streamlined user interface supports faster processing and simplified operation.

Photo diode array (PDA) detection is available with UV and UV-Vis capabilities, allowing spectra to be displayed in real time or after the run. Fraction collection can be based on purity indicators.

Safety and monitoring

An internal vapor sensor detects vapors and automatically stops the system. The detection level is configurable by the user to ensure safe operation.

Active solvent and waste level monitoring comes as standard, helping prevent dry runs and overflow during operation. It also includes a column air purge functionality.

Purification capabilities

Mass-directed purification enables collection of only those fractions that match the mass of the target compound, reducing the need for additional analysis and saving time in post-purification workflows.

An integrated evaporative light scattering detector (ELSD) allows detection and collection of non-chromophoric and non-volatile compounds. The ELSD is fully integrated into the system, requiring no additional footprint. Parameters are automatically set based on the solvent or optimizable for specific separations, supporting a wide sample load range.

Customization and configuration

The CombiFlash NextGen 300 is configurable to match user requirements. Optional features include RFID rack and column recognition for improved workflow efficiency.

The system allows users to select only the features they need, avoiding unnecessary complexity or investment in unused functionality.

Focus Gradient Generator

The Focus Gradient Generator, integrated into PeakTrak® software, enables predictive method development. After a preset gradient run, the user can select the target peak, and the system generates an optimized gradient method focused on that compound.

Specifications 

No more TLC plates for flash. Really?

Yes, really, with the Focused Gradient Generator for flash. Read the info here.