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ChemSPX supports pharmaceutical laboratories across the Benelux with advanced laboratory instruments, analytical solutions, and application expertise. With decades of experience, we help pharmaceutical professionals throughout every stage of drug development and production, from early research and process development to formulation, quality control, and manufacturing. Our solutions help laboratories optimize workflows, achieve reliable and reproducible results, and maintain high standards of quality and compliance.
Pharmaceutical applications
With decades of experience supporting research, development, quality control, and manufacturing laboratories, we help pharmaceutical organizations accelerate innovation while maintaining the highest standards of quality and compliance.
Our portfolio covers solutions for every stage of pharmaceutical drug development and production, from early discovery and process development to scale-up and manufacturing. We provide advanced technologies for purification, batch processing, flow chemistry, green chemistry, reactor platforms, formulation development, and analytical characterization, helping scientists optimize workflows, improve efficiency, and bring new therapies to market faster.
Whether you are developing active pharmaceutical ingredients (APIs), optimizing synthetic routes, scaling chemical processes, or formulating final drug products, we offer the expertise, instrumentation, and application support needed to achieve reliable and reproducible results.
Purification
Purification techniques represent a cornerstone of pharmaceutical research and development (R&D), playing a pivotal role in the discovery, optimization, and manufacturing of safe and effective medicines. Throughout the drug development lifecycle, the isolation of target compounds from complex reaction mixtures and process-related impurities is essential to ensure product quality, reproducibility, and regulatory compliance.
Whether developing small molecule active pharmaceutical ingredients (APIs), biologics, peptides, or advanced therapeutic modalities, purification strategies directly influence compound integrity, process efficiency, and downstream manufacturability.
Why is purification important during drug development?
In pharmaceutical R&D, purification is not merely a final polishing step but an integrated scientific discipline that impacts medicinal chemistry, analytical development, process chemistry, formulation science, and scale-up activities.
During early-stage discovery, purification methods enable researchers to isolate and characterize novel compounds with sufficient purity for biological screening and structure confirmation. As projects progress into preclinical and clinical development, purification processes must become increasingly robust, scalable, and economically viable while maintaining strict quality standards in accordance with regulatory frameworks such as Good Manufacturing Practice (GMP).
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Application notes
Large-scale flash purification
CombiFlash Torrent
Automates large-scale flash purification with flow rates up to 1 L/min and sample loads up to 300 g. Supports normal and reverse phase separations with flexible detection.
Preparative HPLC purification
ACCQPrep HP150
Simplifies HPLC purification with flow rates up to 150 mL/min and pressures up to 6,000 psi. Features automated gradient optimization, flexible detection and accurate fraction collection.
Preparative SFC purification
ACCQPrep SFC
Enables chiral and achiral separations using supercritical CO₂, with flow rates up to 200 mL/min. Reduces organic solvent consumption while providing automated fraction collection and high sample recovery.
Flash chromatography purification
CombiFlash NextGen 300
Enables preparative flash purification with flow rates up to 300 mL/min and pressures up to 300 psi. Features flexible detection options, automated solvent monitoring and optimized gradient methods.
Automated flash chromatography
CombiFlash NextGen 300+
Enables flash purification with flow rates up to 300 mL/min and pressures up to 300 psi. Features RFID column recognition, automated gradient optimization and flexible detection options.
Flash chromatography purification
CombiFlash NextGen 100
Supports normal and reverse phase flash purification with flow rates up to 100 mL/min and pressures up to 150 psi. Features UV detection, optimized gradient methods and flexible fraction collection.
Flash and preparative HPLC purification
CombiFlash EZ Prep
Combines flash and preparative HPLC purification in one system, with flow rates up to 200 mL/min and pressures up to 3,500 psi. Features flexible detection and seamless switching between purification modes.
Batch processing
Batch processing is not simply a legacy convention in pharmaceutical manufacturing, it is a deliberate, regulatory-aligned production philosophy that continues to define how active pharmaceutical ingredients (APIs) and finished dosage forms are made. Understanding why requires looking at the intersection of regulatory obligation, operational complexity, and scientific precision that characterises modern drug production.
Flexibility for multi-product facilities
Campaign-based batch manufacturing enables pharmaceutical facilities to produce multiple distinct products on shared infrastructure, a critical economic and operational requirement for contract development and manufacturing organisations (CDMOs) and multi-product API plants alike.
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Comparative dissolution tester
CD14
Enables simultaneous or independent dissolution testing with 14 stirring positions and flexible method settings. Supports bioequivalence studies, automated sampling and secure data management.
Automated dissolution sampling
Vision AutoPlus with AutoFill
Automates dissolution sampling and sample collection with 6 or 8 channels. Features precision syringe pumps, flexible collection formats and integration with UV-Vis, HPLC and UPLC workflows.
Dissolution testing
Vision G2 Classic 6
Enables precise dissolution testing with 6 vessel positions, programmable speed and temperature control. Features a compact design, intuitive touchscreen and optional automated sampling.
Dissolution testing
Vision G2 Elite 8
Enables precise dissolution testing with 8 vessel positions and flexible manual or automated operation. Features adjustable drive head, touchscreen control and advanced sampling options.
Microwave digestion system
BLADE
An automated sequential microwave digestion system. It processes vessels individually and allows different samples and acid mixtures to be combined within one sequence
Scientific digestion system
MARSXpress 2.0
A batch microwave system that can process between one and 41 samples. It flexible vessel range makes it suitable for routine digestion across varied sample types.
Flow chemistry
Flow chemistry, also referred to as continuous flow chemistry or micro process technology, involves pumping reagent streams continuously through a reactor rather than charging a fixed volume into a static vessel. Unlike batch chemistry, where an entire reaction mixture ages together over the course of minutes to hours, flow chemistry defines a fixed, controllable residence time for every fluid passing through the system.
This shift from a time-domain process to a space-domain process changes how chemists approach reaction optimization. Rather than controlling reaction time directly, they tune flow rate and reactor length to achieve the desired residence time, alongside traditional variables such as temperature and stoichiometry.
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Scalable continuous flow reactor
SABBRe
Combines batch processing flexibility with flow chemistry performance for efficient process development and scale-up. Features modular configurations, controlled mixing and high heat and mass transfer efficiency.
High-temperature flow chemistry
Phoenix Flow Reactor
Enables homogeneous and heterogeneous flow reactions at temperatures up to 450°C and pressures up to 200 bar. Features interchangeable reactors, precise temperature control and modular expansion options.
Benchtop flow hydrogenation
H-Cube Advance
Enables continuous flow hydrogenation and catalyst screening with on-demand hydrogen generation. Features precise gas flow control, CatCart® catalyst technology and a user-friendly touchscreen interface.
High-flow piston pumps
ReaXus PR Class
Delivers precise flow rates up to 300 mL/min and pressures up to 4,000 psi. Designed for preparative chromatography and process applications, with flexible control and connectivity options.
Discuss your application with our Xperts
Our Xperts are happy to discuss your application and help you find the right solution.