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Dual-function purification system
The CombiFlash® EZ Prep system from Teledyne LABS is a dual-function purification system that enables both flash and preparative (Prep) chromatography on a single instrument. By combining these capabilities, the system removes the need for two separate setups and allows users to switch between flash and Prep HPLC modes without compromising performance.
The system is designed as a compact and easy-to-operate unit, supporting streamlined purification workflows in limited laboratory space.
System specifications
- Pressure up to 3,500 psi (240 bar) and flow rates up to 200 mL/min
- Supports preparative HPLC columns up to 50 mm in diameter, including 5 µm particle size
- Flash purification range from 10 mg to 33 g, followed by final purification on high-performance columns
- Detection options include UV, UV-Vis, ELSD, and MS
- Automatic switching between normal phase and reverse phase solvents without user interaction
Performance and operation
The EZ Prep system works with PeakTrak® software, which provides an intuitive interface and single-screen control of operating parameters and detection modes. This reduces the learning curve and enables efficient purification while helping to save time and solvent.
Both flash and preparative HPLC use the same software platform, allowing users to perform purifications regardless of their level of Prep HPLC experience.
Key system characteristics
- You can perform transition from flash to high-pressure preparative chromatography in two clicks
- Compact design requiring minimal laboratory space
- Compatibility with preparative HPLC columns packed with particles down to 5 µm
Applications
The system is suitable for a wide range of purification applications, including organic synthesis, drug discovery, natural products, food additives, dyes, small molecules, peptides, agrochemicals, inorganic ligands, and other research activities.
| Application | How the CombiFlash EZ Prep is used |
|---|---|
| Peptides | Peptides are separated using the EZ Prep with a RediSep® Prep C8 column to achieve high purity based on structural differences. Compounds with the same molecular weight can be distinguished through mass‑spectral fragmentation patterns. |
| Carbohydrates | Compounds without chromophores are detected using the optional built‑in ELSD. Both flash and preparative HPLC modes can purify carbohydrates. |
| Small molecules | Synthesized compounds are resolved using preparative HPLC columns with UV, ELSD, or mass‑directed fractionation to support detection and collection of target compounds. Operation up to 3,500 psi (241 bar) enables higher flow rates on preparative columns. |
| Natural products | Crude natural‑product mixtures are isolated using flash purification, followed by higher‑purity refinement with preparative HPLC. Capsaicins can be purified on a RediSep Prep C18 column from flash fractions. |
