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Large-scale Flash Purification System
What is the CombiFlash Torrent?
The CombiFlash® Torrent system from Teledyne Labs is ideal for large-scale flash purification, combining the ease of use and reliability of the CombiFlash and RediSep® product lines in a development-scale platform. Controlled by PeakTrak® software, the system supports a wide range of injection, detection, and fraction collection requirements.
The system can perform both normal phase and reverse phase purifications, making it suitable for a broad range of applications.
Safety and automation
The CombiFlash Torrent is equipped with patented active solvent sensing technology that monitors solvent supply and waste levels, enabling true walk-away automation.
Additional safety features include:
- Pressure and vapor sensors that stop purification if pressure increases or detects a leak
- Fully grounded tubing for safe operation at high flow rates
- Optional air purging of the column after use to simplify disposal
Versatility and configuration
You can configure the system to meet specific application needs through a variety of sample introduction and fraction handling options. It supports a wide range of purification workflows, including applications such as natural products, peptides, and oligonucleotides.
Key system capabilities include:
- Binary gradient operation up to 1 L/min
- Sample loading up to 300 grams per run
- Compatibility with both normal phase and reverse phase separations
Control and software
PeakTrak® software provides full system control through a single interface, allowing users to access and modify all method parameters. It supports automated operation, including sequential injections of the same sample without user intervention.
Detection and peak handling
The system offers flexible detection and peak collection options:
- Peak collection can be triggered by slope, threshold, or time windows
- Detection can be performed at one, two, or multiple wavelengths using internal UV or UV-Vis PDA detectors
- Optional Evaporative Light Scattering Detector (ELSD) with a self-contained flow splitter pump minimizes sample loss
- Possibility to integrate external detectors
PeakTrak® software controls a fractionation valve that enables targeted peak collection through detection signals or defined time windows.
Fraction collection and column recognition
The CombiFlash Torrent integrates with fraction collection systems and column recognition technologies:
- RFID-based detection automatically identifies RediSep® columns and selects optimized purification methods
- Compatibility with Foxy® R2 fraction collectors allows mixed rack configurations and supports large numbers of fractions with intelligent rack management
Solvent and sample handling
The system includes multiple options for solvent and sample management:
- Solvent selection valve module allows switching between solvents during a run or within a method
- Ability to purify with one solvent and perform column washing with another
- Dedicated sample loading port for automated injections
- Automated six-port injection valve enabling column equilibration, sample loading, purification, air purge, and post-run cleaning
A sample load cartridge is available for handling low-solubility samples and can also be used as a guard column with reusable columns.
Specifications of the large-scale flash purification system
| Sample size | 0.5–300 g (RediSep® Rf); 80 g–8.6 kg depending on column size |
|---|---|
| Flow rate | 50–1,000 mL/min |
| Maximum pressure | 100 psi (6.89 bar) |
| Detection | 200–400 nm standard 200–800 nm optional Single, dual, or all‑wavelength collection Accepts external detector input |
| Gradient capability | Binary high‑pressure solvent mixing Linear, step, or isocratic modes Two solvent inlets |
| Gradient accuracy | < 2 % full scale from 0.2 to 1.0 L/min |
| Sample injection | Automated injection Solid load cartridges, liquid load, or direct injection |
| Controller | 10.4″ (26.7 cm) touchscreen |
| Software | On‑screen method development and control with PeakTrak software |
| Fraction collection | Up to four fraction collectors, fractionation valve, or manual collection |
| Solvent management | Patented active level sensing for solvent inlet and waste containers |
| Dimensions (W × D × H) | 18.5 × 17.9 × 28.1 in (47 × 43.5 × 71.4 cm) |
| Weight | 65 lb (29.5 kg) |
| Operating voltage | 100 VAC 50 Hz; 117 VAC 60 Hz; 234 VAC 50 Hz |
