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High Performance Liquid Chromatography System
The ACCQPrep HP150 from Teledyne LABS is a high performance liquid chromatography (HPLC) system that is ideal for intuitive operation while maintaining performance and accuracy. The system focuses on purification with high sample recovery.
Ease of use and system design
The ACCQPrep HP150 is ideal to simplify purification by removing unnecessary and complex method parameters commonly found in many HPLC systems. It is controlled by PeakTrak® software, which fully integrates into the system and eliminates the need for a separate PC. This results in a compact unit with a touch screen interface.
Software updates are available at no cost. The system also includes active solvent and waste level monitoring to reduce the risk of spills, and RFID-enabled collection racks to support accurate fraction collection.
Performance and scalability
The system uses dual piston, high-pressure pumps to generate accurate gradients with low dwell volumes. It supports a wide operating range, from analytical flow rates to preparative scale, without requiring pump head changes.
- Flow range from 1 mL/min to 150 mL/min
- Suitable for analytical columns and preparative columns up to 50 mm and larger
- Operating pressure up to 6,000 psi
An analytical column can perform a scouting and can scale up to preparative purification on the same system with a single interaction.
Key system characteristics
- Single-screen control of system parameters
- Compact design for minimal laboratory space usage
- Expandable with automation modules, sample injection, and detection options
- Detection options include UV, UV-Vis, ELSD, and MS
Detection and data handling
UV and UV-Vis detectors use photo diode array (PDA) technology. The system displays spectra in real time or after the run and supports fraction collection using purity indicators.
Focus Gradient Generator
The Focus Gradient Generator exists to reduce purification time and improve resolution around the target compound. After performing a scouting run, the user can select a peak or enter its retention time to generate an optimized gradient method.
- The system automatically scales the method to the selected column size (with matching media)
- Supports improved resolution and increased sample loading
- Reduces method development time
Integration with PurIon MS allows confirmation that the correct peak is selected for optimization.
Scouting and focused runs
You can perform a scouting run (left) on the ACCQPrep HP150 or from a calibrated analytical system. By selecting the peak of interest or entering its retention time, an optimized method for scale-up is generated.
During the focused run (right), improved resolution can be observed, enabling increased sample loading and higher throughput while minimizing method development time.
ELSD and MS integration
An integrated ELSD module allows detection of weak UV-absorbing compounds without requiring additional bench space. It supports a wide range of sample loading and allows easy adjustment of method parameters.
- Peak alignment automatically adjusts for different solvent mixtures and flow rates
- The system maintains alignment across flow rates from 2 to 150 mL/min without requiring hardware changes
