PurIon

Mass Spectrometer for Flash and Prep purifications

What is the PurIon Mass Spectrometer? 

The PurIon™ Mass Spectrometer from Teledyne LABS to provide affordable mass-directed fractionation for laboratories performing flash and preparative purifications. It integrates directly with CombiFlash NextGen, CombiFlash EZ Prep, and ACCQPrep systems to verify the identity of target compounds during purification.

The system is controlled through PeakTrak® software, which offers a single point of control, predefined ionization settings, and the ability to customize parameters to optimize signal strength. The Ion Finder utility allows users to identify fragments and adducts and optimize detection parameters using direct injection prior to purification. The system is suitable for accessibility and ease of use without requiring specialized training.

Mass analysis and operation 

The PurIon is a compact single-quadrupole mass analyzer with an atmospheric pressure interface optimized for chromatography workflows. It provides molecular weight information for target compounds and detects adducts during purification or through direct-injection analysis.

Operation includes:

• Positive ion mode via proton attachment (M+H)+
• Negative ion mode via proton removal (M−H)−

Detection capabilities 

The system enables mass-based isolation of co-eluting peaks by selecting compounds based on their mass-to-charge ratio (m/z). It supports both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), which can be interchanged depending on application requirements.

The PurIon is suitable for both normal-phase and reverse-phase applications and can detect a wide range of molecules, from small to larger compounds, with an extended mass range up to 2000 Da.

System integration

A fluid interface module is included to divert a small portion of the purification flow stream to the mass spectrometer for real-time analysis, enabling continuous monitoring without interrupting the purification process.

Available models 

“S” Model

The S Model operates within a mass range of 10 to 1,200 Da (m/z). It supports both ESI and APCI ion sources, which can be exchanged depending on the application. The system automatically switches between positive and negative ionization modes during a run.

“L” Model 

The L Model extends the operating range to 10 to 2,000 Da (m/z). Like the S Model, it supports interchangeable ESI and APCI ion sources and automatic switching between positive and negative ionization modes during operation. A fluid interface module is also included for continuous sample analysis.

Specifications 

No more TLC plates for flash. Really?

Yes, really, with the Focused Gradient Generator for flash. Read the info here.