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flash chromatography system
Teledyne Labs

CombiFlash NextGen 300+

The CombiFlash NextGen 300+ comes standard with all options installed
Flow rates from 1 to 300 mL/min
Operating pressure up to 300 psi (20 bar)
Includes RFID technology
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Description
Key features
Technical specifications
Applications
Downloads
FAQ

CombiFlash NextGen 300+

What is the CombiFlash NextGen 300+ Flash Chromatography System?

Het CombiFlash NextGen 300+ is a fully featured flash chromatography system designed for efficiency, precision, and safety in laboratory purification workflows. It supports flow rates from 1–300 mL/min and operates at pressures up to 300 psi (20 bar), making it suitable for a wide range of sample types and scales.

How does RFID technology simplify purification? 

This system includes RFID technology that automatically identifies the size and type of RediSep or RediSep Gold® column. The system uses this information to program an optimized gradient and flow rate. RFID also detects the tube rack type, preventing missed or overfilled tubes, ensuring accurate and reliable sample collection.

Why choose the CombiFlash NextGen 300+?

The CombiFlash NextGen 300+ combines automation, safety, and advanced detection into a compact system that simplifies flash chromatography. From predictive gradient generation to mass-directed purification, it is ideal to save time, reduce errors, and maximize efficiency in laboratory workflows.

 

 

No more TLC plates for flash. Really?

Yes, really, with the Focused Gradient Generator for flash. Read the info here.

 

Are you looking for a Synthesis & Purification bundle?

Combine the CEM Discover 2.0 with the Teledyne Labs CombiFlash NextGen 300+

 

Key features

  • Photo Diode Array (PDA) Detection: UV and UV-Vis detectors display spectra in real time or post-run and allow collection based on purity indicators.

  • Mass-directed purification: collect only peaks matching your compound’s mass, reducing the need for post-run analysis.

  • Integrated ELSD: collect non-chromophoric, non-volatile compounds without additional system footprint. Operating parameters are automatically adjusted based on the solvent.

  • Internal vapor sensor: stops the system automatically if it detects vapors (user-configurable).

  • User-friendly interface: 12 or 15-inch touchscreen with improved baseline correction and streamlined workflow.

  • High-performance UV detection: wider dynamic range supports use of absorbing solvents.

Specifications

Flow rate range  1–300 mL/min
Sample loading  Liquid and Manual Solid (standard)
Automated Solid (option at time of purchase)
Column size compatibility  4 g to 330 g (750 g, 1.5 kg and 3.0 kg with
Large Column Holder)
Maximum pressure  Up to 300 psi (20 bar)
Lower pressure limits user defined F10
UV and UV-Vis detection  Variable UV 200–400 nm  or Variable UV-Vis 200–800 nm  (PDA Technology)
Pump type  Dual syringe
Number of solvents  Binary gradient, 4 solvents
Gradient accuracy  1% typical
Programmable gradients  Linear, step, isocratic

Questions about your application?

Our Xperts are happy to answer your questions and provide additional information about this instrument and its applications.

Ask our Xperts

Frequently asked questions

The CombiFlash NextGen 300+ is a fully featured flash chromatography system designed for efficient, precise, and safe purification workflows. It supports flow rates from 1–300 mL/min and operates at pressures up to 300 psi (20 bar), making it suitable for a wide variety of sample types and purification scales.
The system’s RFID technology automatically identifies the installed RediSep or RediSep Gold® column and uses the information to select the optimal gradient and flow rate. RFID also recognizes the tube rack type, preventing missed fractions or overfilled tubes. This ensures accurate, error‑free sample collection.
The CombiFlash NextGen 300+ includes an internal vapor sensor that automatically stops the system when vapors are detected (user‑configurable), reducing exposure risks. RFID identification of column and rack types also prevents operational errors that could compromise safety.
This system combines automation, advanced detection, safety controls, and ease of use in a compact package. With predictive gradient programming and mass‑directed purification, it helps labs save time, improve reliability, and minimize manual re‑analysis.
It accommodates columns from 4 g to 330 g. With the optional Large Column Holder, it can also support 750 g, 1.5 kg, and 3.0 kg columns.
The CombiFlash NextGen 300+ supports linear gradients, step gradients, and isocratic runs.
It features a dual syringe pump, delivering accurate gradients with typical gradient accuracy of 1%.

Downloads

CombiFlash NextGen 300+ datasheet
Download

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