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Benchtop Flow Reactor
The H-Cube Advance is a compact Benchtop Flow Reactor for efficient and safe chemical synthesis. It builds on the award-winning H-Cube and the H-Cube Pro, providing advanced features for labs. This benchtop flow reactor is ideal for modern labs, featuring a push-button synthesis platform with a sleek, user-friendly interface. The reactor enables on-demand hydrogenation, catalyst screening, and a variety of other reactions with precise control.
Advanced hydrogen and gas handling
A key feature of the H-Cube Advance is the integrated Mass Flow Controller, which enables accurate control of both the in situ generated hydrogen and externally supplied gases. This contributes to reproducible reaction conditions and supports process development and scale-up activities.
The reactor produces hydrogen with a purity of 99.9% (3.0 grade) using an advanced water electrolysis system. In addition to hydrogen, a dedicated external gas inlet allows the introduction of other gases through the built-in MFC.
Supported gases include hydrogen, oxygen, nitrogen, carbon monoxide, carbon dioxide, air, argon, ethylene, ethane, methane, helium, nitrous oxide, and nitrogen monoxide.
Improved system design
The H-Cube Advance incorporates several hardware improvements designed to simplify operation and maintenance. The external water reservoir can be configured with flasks of different sizes to suit specific laboratory requirements. Because the reservoir is completely detachable, cleaning is straightforward and convenient.
A next-generation single-cell water electrolysis unit provides efficient on-demand hydrogen production while contributing to longer cell lifetime and reduced maintenance requirements. To maintain water quality and support cell longevity, the system incorporates a water purification cartridge containing ion-exchange resin.
The reactor also features an upgraded internal valve system, an integrated pressure sensor and a built-in mixer module. As a result, no additional external modules are required. The system only requires a compatible ThalesNano HPLC pump.
What is the H-Cube Advance Benchtop Flow Reactor?
The H-Cube Advance is a push-button benchtop flow reactor that combines compact design with advanced functionality. It is used primarily for hydrogenation reactions and catalyst screening in research and development settings. Key capabilities include:
- Built-in MFC for the precise dosing of the produced hydrogen or the treatment of the external gases
- User-friendly interface, ergonomic design
- 3.0 (99.9%) produced hydrogen purity
- Compatibility with the THS ReAction software
How does the H-Cube Advance benchtop flow reactor work?
The H-Cube® Advance is primarily used for hydrogenating a wide range of starting materials and for catalyst screening.
- A reactant solution is introduced into the reactor via an HPLC pump.
- The solution mixes with hydrogen generated on demand, in situ.
- The pre-heated mixture is then passed through a disposable CatCart®, preloaded with the desired solid catalyst.
- The mixture flows through the solid phase and collects in a flask.
- In most cases, the only post-reaction step needed is solvent evaporation.
What are the main features of the H-Cube Advance?
- Built-in Mass Flow Controller (MFC): ensures precise gas control, whether using 99,9% pure in-situ hydrogen or external gasses, for reproducible and scalable synthesis.
- External gas inlet: allows the introduction of additional gasses like oxygen, nitrogen, carbon oxides, and many more.
- External water reservoir: detachable and easy to clean, available in different flask sizes.
- Next-generation water electrolysis cell: efficient single-cell operation for consistent on-demand hydrogen production with extended life and low maintenance.
- CatCart® technology: minimizes exposure to toxic or pyrophoric catalysts; easy-to-use holder with ergonomic lift.
- Upgraded internal and external parts: built-in valve, mixer module, and pressure sensor improve reaction control. Compatible with HPLC or Knauer pumps.
- Touch display with user-friendly interface: external 11.6″ touchscreen for automated or manual operation
What reactions can the H-Cube Advance perform?
Hydrogenation reactions:
- Triple bond full reduction
- Debenzylation
- Nitrile reduction
- Selective nitro reduction
- Selective triple-to-double bond reduction
- Selective double bond reduction
- Aldose reduction
- Aromatic heterocycle reduction
- Aromatic ring reduction
Other reactions:
- Deuteration
- Sonogashira coupling
- Suzuki coupling
Specifications
| Solvent and reagent flow rate range | 0.01–10 mL/min |
|---|---|
| Internal H₂ gas flow rate range | 1–70 NmL/min |
| Gas types | Internal H₂ or other external gases |
| Pressure range | Atmospheric to 100 bar |
| Reactor temperature range | 0–150 °C (32–302 °F) |
| Dimensions (H × W × D) | 330 × 320 × 330 mm (without display) |
| Display size | 11.6″ (29.464 cm) |
| Weight | 18 kg |
| Mains range | 110–240 V AC, 50/60 Hz, 500 W |
Also available in Hastelloy
Het Hastelloy version of the H-Cube® Advance hydrogenation flow reactor offers a larger reaction space compared to its stainless steel counterpart. With the entire liquid path made from Hastelloy C, this version provides enhanced chemical resistance for more demanding applications.
