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Flash Chromatography System for normal and reverse phase purifications
What is the CombiFlash® NextGen 100?
The CombiFlash® NextGen 100 from Teledyne Labs is a flash chromatography system for both normal phase and reverse phase purifications. It operates at flow rates up to 100 mL/min and pressures up to 150 psi (10 bar), offering an economical solution for routine purification workflows.
System design and performance
The system can handle a wide range of purification needs while maintaining a compact and cost-effective setup. It supports collection of purified compounds in different rack sizes, allowing appropriate fraction volumes depending on column size.
Flow and pressure capabilities include:
- Flow rates from 1 to 100 mL/min
- Operating pressure up to 150 psi (10 bar)
Focus Gradient Generator
The Focus Gradient Generator is integrated into PeakTrak® software and supports predictive method development. After a preset gradient run, the user can select a target peak, and the system automatically generates an optimized gradient method focused on that compound.
Key features
- Wider dynamic range UV detector with improved baseline correction for absorbing solvents
- Faster processing through a streamlined user interface
- Photo diode array (PDA) detection using UV and UV-Vis technology
- Real-time or post-run spectral display
- Fraction collection based on purity indicators
Detection and purification options
The system supports multiple advanced detection and collection strategies:
Internal vapor sensor
When the system detects vapors, it automatically stops operation.
Mass-directed purification
Fraction collection can be based on matching the mass of the target compound, reducing the need for additional post-purification analysis and saving time.
ELSD detection
An integrated evaporative light scattering detector (ELSD) allows collection of non-chromophoric and non-volatile compounds. It is fully integrated into the system, requiring no additional footprint. All parameters are automatically configured based on the solvent used or can be optimized for the separation.
Specifications
| Flow rate range | 1–100 mL/min |
|---|---|
| Pressure limit | 150 psi (10 bar) |
| Column sizes | 4–330 g |
| Sample size | 10 mg–10 g |
| User interface | 12 in touchscreen (30.5 cm) |
| Dimensions (H × W × D) | 26 × 14.1 × 17 in (66 × 36 × 43 cm) |
No more TLC plates for flash. Really?
No more TLC plates for flash. Really?Yes, really, with the Focused Gradient Generator for flash. Read the info here.
