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Elevated Temperature Cleavage System
The Razor system elevates temperature peptide cleavage, enabling faster workflows and improved peptide purity. By using precision heated reactions, the system supports more complete removal of protecting groups while maintaining reliable and reproducible results.
Up to 12 peptides can be cleaved simultaneously in 30 minutes or less, providing a high-throughput approach where cleavage speed matches downstream purification workflows.
Faster cleavage and accelerated workflows
The Razor system enables both rapid microcleavage and full cleavage:
- Microcleavage can be performed in as little as 2 minutes, providing mass spectrometry-level confidence that amino acids are fully coupled before scale-up
- Full cleavage after synthesis can be completed in 30 minutes or less, helping to accelerate purification workflows
This allows laboratories to move from synthesis to purified peptides faster than with conventional methods.
Improved peptide purity through elevated temperature
Elevated temperature accelerates removal of protecting groups, including more difficult ones such as Pbf. Heat increases molecular motion, improving access of cleavage and scavenging reagents to hydrophobic and sterically hindered regions of peptides.
This supports more complete cleavage and contributes to improved peptide purity, particularly in combination with automated microwave peptide synthesis workflows.
ReliabilityÂ
The Razor system is designed for high-throughput cleavage while minimizing impact on peptide synthesis instrumentation. Harsh cleavage reagents and scavengers can cause wear on automated peptide synthesizers.
The system uses a simple design without a complex valve block system, reducing the need for maintenance. Disposable vessels simplify cleanup and help maintain peptide purity.
Key capabilities
- Cleave up to 12 peptides in parallel at elevated temperatures
- More complete cleavage contributes to improved peptide purity
- Helps protect automated peptide synthesizers from harsh cleavage reagents
- High-throughput cleavage designed for faster purification workflows
