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Pilot scale bioreactor with leading technology and flexibility
The ePILOT® is made of stainless steel AISI 304 and 316L. It is a crucial tool in upstream processes, providing exceptional productivity in both cell culture and microbial fermentation. Its design, crafted to meet diverse client demands, prioritises efficient culture growth and offers various vessel sizes for seamless scale-up productions.
Integrating a PLC into our bioreactor improves bioprocessing success by providing flexible programming, ensuring a comprehensive understanding of each stage of the process.
Our pilot scale bioreactor features advanced monitoring systems. These systems enable the real-time tracking of crucial parameters like pH, pO2, temperature, and foam levels. This tracking ensures ideal conditions for the growth and development of cells and microorganisms.
Some key features
- Modular vessel design
The ePILOT Bioreactor’s vessel design is versatile for adjusting volumes in bioprocessing. It allows for customization of equipment features to meet user needs by exchanging different sized stainless steel vessels for microbial or cell cultures, making it an excellent solution for scaling up production. (When changing vessels, acquire a flexible hose kit for proper connection and optimal system operation.) - Advanced control system
With a 15-inch touch screen interface, our pilot scale bioreactor provides an intuitive control system. This system facilitates the monitoring and adjustment of key parameters in culture growth, ensuring maximum accuracy in the process. - Precision monitoring
Composed of a set of digital sensors, the system controls and monitors pH, pO2, temperature, and level/foam in real-time. This level of oversight is a cornerstone in achieving high-quality biotechnological outcomes, which guarantees optimal conditions for the growing and development of both cells and microorganism. - Sterilization capabilities
The ePILOT Bioreactor ensures excellent hygiene and sterilization through the use of steam. Available in two versions: the “External SIP version” for sites that can produce steam, and the “AUTOSIP version” for sites that cannot, which comes with built-in electric heaters to create steam directly within the equipment. - Optmized agitation system
This pilot scale bioreactor provides two precision-controlled impellers: the 6-blade Rushton turbine for microbial fermentation and the 3-pitched blade for cell culture. Governed by a servomotor, these impellers maximize efficiency and productivity by adjusting agitation velocity and intensity, delivering a power of 400W for optimal bioprocessing performance.
Key strategies for effective scalability in pilot scale bioreactors
TECNIC ePILOT® bioreactor offers a unique solution in scalability and adaptability, allowing for the interchangeability of vessels1 between the cellular and microbial versions. Essential for laboratories and production plants, seeking flexibility in their cell culture and microbial fermentation processes.
With working volumes of 10, 20, 30, and 50 liters, the interchangeable vessels of the ePILOT® facilitate the transition between different scales of production or research, without the need to invest in multiple systems. The bioreactor is dedicated to precision and adaptability, with real-time monitoring through integrated sensors.
Key components include: external jacket, sparger, overlay gas inlets, rupture disc, addition valves, and ports for sensors, sampling kit, a bottom valve and a front-integrated sight glass allows monitoring of crucial parameters like turbidity and agitation.
