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Preparative SFC – Supercritical Fluid Chromatography system
What is the ACCQPrep® SFC system?
The ACCQPrep® SFC Supercritical Fluid Chromatography system from Teledyne LABS is a compact preparative SFC solution for both chiral and achiral separations. It combines ease of use with high performance in a single system.
The platform simplifies method development and improve accessibility for users of all experience levels. It supports both bulk collection from injections and multi-sample open-access workflows within a compact footprint.
Green and efficient chromatography
Supercritical CO₂ is used as the primary mobile phase. It is environmentally friendly, cost-effective, and reduces the use of strong organic solvents by up to 95%. This results in lower solvent waste and reduced environmental impact while maintaining high separation efficiency.
CO₂ is non-toxic, non-flammable, and easy to remove from samples. It can also be reused or captured from other processes, supporting more sustainable workflows.
System design and performance
To manage the properties of supercritical CO₂, the system integrates a robust CO₂ pumping system, an advanced mass-flow controller, and automated backpressure regulation. These components ensure stable flow control under varying conditions.
A patented Gas-Liquid Separator (GLS) reduces carryover and resists clogging, while supporting high cosolvent flow before fraction and waste collection. A standard fractionation valve distributes collected fractions into up to eight vessels or directs them to SFC AutoSampler systems for open-bed collection, achieving over 95% recovery at flow rates up to 200 mL/min.
Flow rates range from 50 to 200 mL/min, and the system is designed for columns up to 3 cm.
Software and control
The system operates through PeakTrak® software, accessible via an integrated 15-inch touchscreen interface. Method setup includes gradient, temperature, and backpressure parameters. The software automatically calculates GLS and fraction collection delay settings based on cosolvent composition.
PeakTrak® simplifies method development and reduces the learning curve while allowing remote control via network connection.
Detection and fraction collection
UV and UV-Vis detectors use photo diode array (PDA) technology, allowing spectra to be displayed in real time or after runs. Fraction collection can be based on purity indicators.
A fractionation valve directs collected material into up to eight vessels or external collection systems.
Multiple injection modes
The system supports multiple injection modes:
- Single injections
- Multiple injections
- Stacked injections
An AutoInjector can be combined with an SFC AutoSampler for multi-sample processing, automated wash cycles, and improved repeatability. RFID-enabled collection racks reduce errors such as missed or overfilled tubes.
Advantages of SFC compared to HPLC
Although SFC operates on similar principles to HPLC, the use of supercritical CO₂ allows significantly higher flow rates. As a result, SFC is typically three to four times faster than HPLC.
Additional advantages include:
- Reduced solvent consumption (up to 95% less strong solvent use)
- Lower solvent waste generation
- Up to seven times lower energy consumption for solvent removal
- Environmentally friendly operation with reduced hazardous solvent use
- CO₂-neutral potential through reuse of captured CO₂
- Suitability for food and pharmaceutical applications when combined with appropriate co-solvents
