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CD14 Comparative Dissolution Tester
The Teledyne Labs CD14 Comparative Dissolution Tester is designed for comparative dissolution studies and allows two methods to run either simultaneously or independently. It is particularly suitable for bioequivalence studies comparing generic and innovator formulations, while also supporting workflows in R&D, formulation development, quality control, and stability testing.
The system features 14 stirring positions configured as either 6+1 or 12+2, helping laboratories improve throughput and workload efficiency. Digital temperature probes at 12 positions allow two formulations to be tested under the same temperature conditions while using different parameter settings.
Features
The CD14 combines high capacity with a compact footprint measuring 85 cm × 61 cm.
Key productivity features include:
- 14 stirring positions with 6+1 or 12+2 configurations
- Spindle speed: 25 to 250 rpm
- Temperature: programmable from 25 to 51 °C
- Digital temperature probes: 10 to 60 °C
- Storage for up to 500 methods directly on-board
- Rugged water bath with a low-position front drain port
- Large color touchscreen with adjustable tilt angle
- Compatibility with Apparatus 1, 2, 5, and 6
- Integration with CD AutoPlus™ autosamplers and AutoFill™ fraction collectors
The instrument also includes a precision vessel centering system designed to meet demanding enhanced mechanical specifications.
Advanced computer control and software capabilities
The CD14 uses an integrated computer built directly into the color touchscreen display mounted on the drive head. The Linux-based operating system and built-in SQL database provide rapid response and data handling.
Software capabilities include:
- Fast programming of new methods
- Search functionality across multiple database fields
- Import and export options including full system backup
- Event, error, service, and test history logs
- Programmable alarms for automatic power-on and warm-up
- Countdown timers for sampling points
- Built-in diagnostics tools
- Context-sensitive help
- Firmware languages include English, Chinese, Korean, and Spanish
The resistive touchscreen can be operated while wearing gloves and supports multiple user environments.
21 CFR PART 11 compliance
The CD14 includes security and audit functions intended for regulated environments.
Features include:
- Support for up to 100 users
- Three security levels: operator, manager, and administrator
- Customizable user profiles
- Biometric fingerprint identification or password-only login
- Audit trail recording system events and user changes
- Configurable reports with up to three signatures
- On-board storage of configuration changes and method modifications
Serialized components
Critical system components are identified with unique serial numbers traceable back to the factory.
Serialized items include:
- Spin shafts
- Dissolution vessels
- Baskets
- Paddles
Vessel identification information is laser engraved on the rim, ensuring traceability remains available even if glass breakage occurs. The system database stores component serial numbers together with installation positions.
Precision vessel centering system
Each dissolution vessel is mounted in an adjustable bracket attached to the vessel plate. These brackets allow precise alignment of the vessel relative to the spin shaft and attached apparatus.
This design supports fast vessel adjustment while helping laboratories meet or exceed USP and ASTM mechanical calibration requirements.
Specifications
| Weight | Dry | 118 kg (260 lb) |
|---|---|---|
| Bath and vessels filled with water | 174 kg (383 lb) | |
| Dimensions | H × W × D | 87.6 × 67.3 × 58.5 cm (40.0 × 33.5 × 24.0 in.) |
| Bath | Capacity | 41.6 liters (11 gallons) with 14 vessels |
| Power | Input | 100–230 V ± 10 %, 50–60 Hz, max. 1.5 A |
| Output | 24 VDC, 3.75 A, 90 W | |
| Spindle speed | Range | 25–250 rpm |
| Accuracy | ± 1 rpm | |
| Displayed resolution | 0.1 rpm | |
| Temperature | Programmable range | 25.0–51.0 °C |
| Accuracy | ± 0.5 °C | |
| Control stability | ± 0.1 °C | |
| Digital temperature probes | Range | 10–60 °C |
| Accuracy | ± 0.1 °C (30–55 °C) | |
| Displayed resolution | 0.01 °C | |
| Minimum submersion depth | 25 mm | |
| Response time | < 45 seconds (typically ~30 seconds) |
Find the perfect Dissolution Testing Solution for your needs
Teledyne Labs has developed an unique online configurator. Tailor your very own dissolution system based on your unique requirements and preferences!
With this user-friendly tool, you can effortlessly design a system that perfectly aligns with your specific needs, ensuring maximum efficiency and productivity. From selecting dissolution baths to choosing specific accessories, the possibilities are endless!
